Arginine Deficiency
نویسندگان
چکیده
منابع مشابه
Effect of arginine deficiency on arginine-dependent post-translational protein modifications in mice.
Transgenic mice that overexpress arginase-I in their small-intestinal enterocytes suffer from a pronounced, but selective decrease in circulating arginine levels during the suckling period, resulting in impaired growth and development of hair, muscle and immune system. In the present study, we tested the hypothesis that the arginine-deficiency phenotype is caused by arginine-specific post-trans...
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Cystic fibrosis affects multiple organs but lung disease remains the major determinant of patient morbidity and mortality. Cystic fibrosis lung disease is characterized by chronic infection and inflammation. The amino acid L-arginine is substrate for both nitric oxide synthases and arginases. The activity of arginase in sputum is increased while the production of nitric oxide is reduced in the ...
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The purpose of this case study is to report the use of oral Bovril (a food supplement which contains arginine) as an alternative test for growth hormone stimulation test. We performed oral Bovril test in 3 patients -- one with suspected growth hormone deficiency in whom insulin tolerance test could not be performed (subject A), one sex-matched control (subject B), and one with confirmed growth ...
متن کاملArginase-1 Deficiency Regulates Arginine Concentrations and NOS2-Mediated NO Production during Endotoxemia
RATIONALE AND OBJECTIVE Arginase-1 is an important component of the intricate mechanism regulating arginine availability during immune responses and nitric oxide synthase (NOS) activity. In this study Arg1(fl/fl)/Tie2-Cre(tg/-) mice were developed to investigate the effect of arginase-1 related arginine depletion on NOS2- and NOS3-dependent NO production and jejunal microcirculation under resti...
متن کاملFifteen-year follow-up of Italian families affected by arginine glycine amidinotransferase deficiency
BACKGROUND Arginine:glycine amidinotransferase deficiency (AGAT-d) is a very rare inborn error of creatine synthesis mainly characterized by absence of brain Creatine (Cr) peak, intellectual disability, severe language impairment and behavioural disorder and susceptible to supplementary Cr treatment per os. Serial examinations by magnetic resonance spectroscopy are required to evaluate Cr recov...
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ژورنال
عنوان ژورنال: Nature
سال: 1973
ISSN: 0028-0836,1476-4687
DOI: 10.1038/246319c0